Can i use ziana during the day

Unacceptable facial hair includes, but is not limited to, beards, and long side-burns. A well-trimmed mustache is acceptable. Patients who have performed wax epilation of the face within 14 days prior to baseline will also be excluded from study participation. Patients who engage in activities that involve excessive or prolonged exposure to sunlight or weather extremes, such as wind or cold, will be excluded from study participation.

Patients who consume excessive amounts of alcohol greater than two drinks per day or use drugs of abuse including, but not limited to, cannabinoids and cocaine as judged by history will be excluded from study participation.

Patients who have participated in an investigational drug study i. Patients who are participating in non-treatment studies such as observational studies or registry studies can be considered for inclusion. Patients who have been previously enrolled in this study will be excluded from study participation.

Patients who have had within 30 days prior to baseline or during the study cryodestruction or chemodestruction, dermabrasion, photodynamic therapy, acne surgery, intralesional steroids, or x-ray therapy will be excluded from study participation.

Patients who have had laser therapy, and electrodesiccation to the facial area within days prior to study entry will be excluded from participation. Patients who have had cosmetic procedures e. Patients who have had general anesthesia for any reason and patients who have received neuromuscular blocking agents within 14 days prior to study entry will be excluded from study participation.

Patients who have a history of Crohn's disease, ulcerative colitis, regional enteritis, antibiotic-associated colitis will be excluded from study participation.

Hide glossary Glossary Study record managers: refer to the Data Element Definitions if submitting registration or results information.

Search for terms. Save this study. Warning You have reached the maximum number of saved studies Bioequivalence Study Comparing Clindamycin Phosphate 1. Listing a study does not mean it has been evaluated by the U. Federal Government. Read our disclaimer for details. Last Update Posted : December 10, Study Description.

FDA Resources. Arms and Interventions. Outcome Measures. Primary Outcome Measures : Therapeutic Equivalence [ Time Frame: weeks ] The primary equivalence comparison is that between the test and reference products for the mean percent change from baseline in the inflammatory lesion counts and the non-inflammatory lesion counts at Visit 5.

The primary superiority evaluations are the comparisons between each active treatment and the vehicle control relative to the mean percent change in the inflammatory lesion counts and the non-inflammatory lesion counts. All treatment-emergent adverse events reported during the study will be summarized in order to assess safety. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision.

Inclusion Criteria: 1. Exclusion Criteria: 1. You should not use clindamycin and tretinoin topical if you are also taking another antibiotic called erythromycin, or using other skin medications that contain erythromycin. Tretinoin is a form of vitamin A. It reduces the amount of oil released by oil glands in your skin, and helps your skin renew itself more quickly. Clindamycin and tretinoin is a combination medicine used to treat severe nodular acne in adults and children who are at least 12 years old.

Clindamycin and tretinoin topical may also be used for purposes other than those listed in this medication guide. Although this medicine is applied to the skin, your body may absorb enough clindamycin to affect certain medical conditions you may have.

You should not use this medication if you are allergic to clindamycin or tretinoin, or if you have:. FDA pregnancy category C. It is not known whether clindamycin and tretinoin topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether clindamycin and tretinoin topical passes into breast milk or if it could harm a nursing baby.

You should not breast-feed while using this medicine. Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Using more medicine or applying it more often than prescribed will not make it work any faster, and may increase side effects. Use only a pea-sized amount of clindamycin and tretinoin topical.

Apply to your entire face every night at bedtime. Do not wash your face more than 3 times daily while using this medication. Washing more often or scrubbing your face when you wash it can make your acne worse.

Avoid getting this medication in your eyes, mouth, or nose or in the creases of your nose , or on your lips. If it does get into any of these areas, wash with water. Do not apply this medicine to sunburned, windburned, dry, chapped, irritated, or broken skin. Use this medication for the full prescribed length of time, even if you think it is not working.

Call your doctor if skin irritation becomes severe or if your acne does not improve after several weeks of using this medicine. If you need surgery, tell the surgeon ahead of time that you are using clindamycin and tretinoin topical.

Use the medication as soon as you remember the missed dose. If it is almost time for your next dose, skip the missed dose and use the medicine at your next regularly scheduled time. Do not use extra medicine to make up the missed dose. However, no geriatric-specific problems have been documented to date. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding.

Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur.

In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you.

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine.

Make sure you tell your doctor if you have any other medical problems, especially:. It is very important that you use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause your skin to become too dry or irritated.

You may need to use this medicine for several weeks or months before your skin starts to look better. Applying extra medicine will not make it work faster. This medicine is for use on the skin only. Do not get it in your eyes, mouth, nose, on the corners of your nose, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away. This medicine comes with a patient information insert.

Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label.